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Archive for the ‘Warnings’ Category

Cytotec (generic name Misoprostol) first hit the market as a prescription drug for the prevention of ulcers. It was supposed to counteract the unfortunate side effects of certain medications for arthritis and pain relief that cause a higher rate of ulcers (I think I’d rather have the arthritis, personally!). The FDA ran trials and approved it for this use only.

However, it was soon discovered that, given to a pregnant woman, a low dose of Cytotec will successfully start labor contractions at a fraction of the cost of pitocin. So, doctors began giving the drug “off-label” to millions of women.

So, what’s the big deal? you may ask. It works, doesn’t it? Well, I’ll tell you what the big deal is.

Cytotec kills women and babies.

That’s a pretty big deal, right?

I’ll say it again: using Cytotec for induction can kill or seriously injure both the mother and baby.

One unfortunate side effect of misoprostol is that it can cause uterine rupture, which is life-threatening because the uterus detaches from the mother’s body. It causes severe bleeding, fetal distress, and the baby or placenta can be delivered into the mother’s abdominal cavity, rather than through the birth canal. Mothers who experience uterine rupture need an immediate cesarean to get the baby out and to repair or remove the uterus. The mortality rate for women who have a uterine rupture is extremely high, and their babies either die or are left seriously disabled.

The deaths of healthy mothers and babies should be enough to keep doctors from giving the pill to anyone. However, it gets worse. The most shocking part of the use of Cytotec in this way is that the manufacturing company, Pfizer, clearly labels each bottle with a warning against using the drug on pregnant women. When doctors ignored it, they sent out an extra warning to all healthcare practitioners involved in prenatal care and childbirth:

The purpose of this letter is to remind you that Cytotec administration by any route is contraindicated in women who are pregnant because it can cause abortion…

Serious adverse events reported following off-label use of Cytotec in pregnant women include maternal or fetal death; uterine hyperstimulation, rupture or perforation requiring uterine surgical repair, hysterectomy, or salpingo-oophorectomy; amniotic fluid embolism; severe vaginal bleeding, retained placenta, shock, fetal bradycardia and pelvic pain.

(This excerpt was taken from the actual letter. If I knew how I would scan the whole letter and add it to the post, but I’m not quite that technologically adept yet).

With all the reasons not to give Cytotec to any pregnant woman, you would think that no doctor would ever do so. And yet, even with the warnings and evidence of danger, women are still given this drug to induce labor and the fatalities continue.

The biggest question is, of course, why?! If it causes so much damage, why on earth would doctors continue to prescribe it? There are only two reasons I can think of that Cytotec would be given for induction rather than pitocin: money and convenience. Cytotec is much cheaper than pitocin to induce labor, and it is also extremely easy to use: just pop a pill early in the morning, and the baby is out by evening. Or dead by evening.

To all mothers-to-be, please, please do not allow anyone to give you Cytotec! Remember, it is also called misoprostol. If you choose to be medically induced for any reason, make sure you are given pitocin via IV rather than a pill that is either taken orally or placed in the vaginal opening. It is not worth the risk to you or your baby.

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